SCHEMBL4053560

SCHEMBL4053560

CC(OC(=O)N1CCC(COc2cnc(-c3ccc(S(C)(=O)=O)cc3)cn2)CC1)C1CC1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.52
GPR183 P32249 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL384779 0.94 GPR119 (0.58) GPR119
SCHEMBL4053229 0.87 GPR119 (0.61) GPR119GPR183
SCHEMBL4049838 0.87 GPR119 (0.49) GPR119GPR183
SCHEMBL4055470 0.86 GPR119 (0.45) GPR119GPR183
SCHEMBL4056120 0.84 GPR119 (0.51) GPR119GPR183
SCHEMBL4048734 0.84 GPR119 (0.49) GPR119
SCHEMBL4055083 0.83 GPR119 (0.44) GPR119GPR183
SCHEMBL385347 0.83 GPR119 (0.60) GPR119
SCHEMBL387669 0.83 GPR119 (0.60) GPR119
SCHEMBL388467 0.83 GPR119 (0.60) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009106561-A1 PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS BIOVITRUM AB (PUBL) (SE) 2009-09-03 WO disclosed
WO-2009106561-A1 PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS BIOVITRUM AB (PUBL) (SE) 2009-09-03 WO disclosed