Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057662 | 0.93 | HRH3 (0.61) | HRH3SMN1; SMN2MAPK1LMNAHPGD | |
| SCHEMBL1374951 | 0.85 | HRH3 (0.58) | HRH3SMN1; SMN2MAPK1LMNAHPGD | |
| SCHEMBL4054433 | 0.78 | HRH3 (0.64) | HRH3SMN1; SMN2MAPK1LMNAHPGD | |
| SCHEMBL4059203 | 0.78 | HRH3 (0.64) | HRH3LMNAALDH1A1PSMB5HTT | |
| SCHEMBL4056854 | 0.77 | HTR3A (0.46) | HRH3 | |
| SCHEMBL1376883 | 0.76 | HRH3 (1.00) | HRH3SMN1; SMN2MAPK1LMNATSHR | |
| SCHEMBL5258160 | 0.76 | KCNH2 (0.51) | HRH3 | |
| SCHEMBL1375438 | 0.75 | HRH3 (1.00) | HRH3 | |
| SCHEMBL1375436 | 0.75 | HRH3 (1.00) | HRH3 | |
| SCHEMBL1372565 | 0.75 | HRH3 (1.00) | HRH3SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | claimed |
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |