Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.51 |
| ▸ | NPY1R | P25929 | 8/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055475 | 0.87 | HRH3 (0.66) | HRH3NPY1R | |
| SCHEMBL4057662 | 0.81 | HRH3 (0.61) | HRH3ALDH1A1LMNAPSMB5PSMB1 | |
| SCHEMBL1374615 | 0.78 | HRH3 (1.00) | HRH3ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4053680 | 0.78 | HRH3 (0.61) | HRH3ALDH1A1LMNAHTTPSMB5 | |
| SCHEMBL4065549 | 0.77 | HRH3 (0.49) | HRH3NPY1RACP1 | |
| SCHEMBL1372685 | 0.77 | HRH3 (1.00) | HRH3ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1372688 | 0.77 | HRH3 (1.00) | HRH3ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28283793 | 0.76 | NPY1R (0.57) | NPY1R | |
| SCHEMBL16588429 | 0.73 | HRH3 (0.64) | HRH3ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4056854 | 0.71 | HTR3A (0.46) | HRH3NPY1RACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | claimed |