Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451431 | 0.81 | XDH (0.49) | KDM5BKMOALDH1A1KDM4EMAPT | |
| SCHEMBL4709224 | 0.79 | GSK3B (0.50) | KDM5BMAP4K4ALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL29856925 | 0.79 | XDH (0.47) | KDM5BKMOALDH1A1KDM4EMAPT | |
| SCHEMBL29417027 | 0.79 | PARP1 (0.44) | HSD11B1PARP1MAP4K4ALDH1A1 | |
| SCHEMBL4058328 | 0.77 | PDE2A (0.47) | PARP1NOTUMMAPKAPK2 | |
| SCHEMBL30952085 | 0.77 | ABL1 (0.39) | HSD11B1PARP1KDM5B | |
| SCHEMBL21359186 | 0.75 | KDM5B (0.39) | HSD11B1KDM5BALDH1A1KDM4EMAPKAPK2 | |
| SCHEMBL10688603 | 0.73 | PDE4A (0.59) | ALDH1A1KDM4EGAAMAPTTHRB | |
| SCHEMBL29465046 | 0.72 | AURKA (0.40) | HSD11B1PARP1KDM5BMAP4K4MAPK1 | |
| SCHEMBL16983733 | 0.72 | PARP1 (0.41) | HSD11B1PARP1KMOALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137270-A2 | AZETIDINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009120655-A1 | INDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2009-10-01 | — | — | WO | disclosed |