Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 3/20 | 0.39 |
| ▸ | FABP1 | P07148 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057268 | 0.84 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2ALDH1A1RAB9AMAPK14 | |
| SCHEMBL4056491 | 0.83 | LMNA (0.46) | LMNASMN1; SMN2MAOAGAA | |
| SCHEMBL4060100 | 0.80 | MAPT (0.53) | LMNASMN1; SMN2ALDH1A1MAPTGAA | |
| SCHEMBL4061889 | 0.72 | PBRM1 (0.50) | TNFALDH1A1MAPTRAB9ACYP19A1 | |
| SCHEMBL8227049 | 0.72 | PBRM1 (0.47) | MAOBMAOAESR1ESR2UGT1A1 | |
| SCHEMBL29595598 | 0.72 | PBRM1 (0.47) | MAOBMAOAESR1ESR2UGT1A1 | |
| SCHEMBL27325981 | 0.68 | ESR1 (0.46) | LMNASMN1; SMN2ALDH1A1MAPTRAB9A | |
| SCHEMBL24026848 | 0.67 | CACNA2D1 (0.54) | — | |
| SCHEMBL11089109 | 0.66 | TDP1 (0.69) | ALDH1A1MAPTRAB9ACYP19A1MAOB | |
| SCHEMBL3741412 | 0.66 | MAOA (0.67) | TNFALDH1A1MAPTRAB9AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| US-7557212-B2 | Tricyclic derivatives as LTD4 antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-07-07 | — | — | US | disclosed |
| EP-1560834-B1 | NEW TRICYCLIC DERIVATIVES AS LTD4 ANTAGONISTS | ALMIRALL LAB (ES) | 2008-06-25 | — | — | EP | disclosed |