Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.63 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375437 | 0.77 | HRH3 (0.73) | HRH3 | |
| SCHEMBL4060149 | 0.77 | HRH3 (0.59) | HRH3HTR3AACP1 | |
| SCHEMBL6634225 | 0.76 | ITGB3 (0.47) | HRH3ITGB3ITGA2BMAOBMAP2K1 | |
| SCHEMBL6144124 | 0.75 | ITGB3 (0.46) | HRH3ITGB3ITGA2BMAOBMAP2K1 | |
| SCHEMBL6632127 | 0.75 | ITGB3 (0.61) | HRH3ITGB3ITGA2B | |
| SCHEMBL4055751 | 0.74 | HRH3 (0.46) | HRH3HTR3ABRD4NPY1RACP1 | |
| SCHEMBL6144192 | 0.74 | ITGB3 (0.55) | HRH3ITGB3ITGA2B | |
| SCHEMBL4066805 | 0.71 | HRH3 (0.65) | HRH3NPY1R | |
| Hydrochloric Acid SCHEMBL6632289 | 0.70 | HRH3 (0.55) | HRH3ITGB3ITGA2BMAP2K1NPY1R | |
| SCHEMBL6630382 | 0.70 | DRD2 (0.47) | HRH3ITGB3ITGA2BMAP2K1ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2492263-A1 | Pyridizinone Derivatives | Cephalon, Inc. (US) | 2012-08-29 | — | — | EP | claimed |
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |