Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.63 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.63 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.60 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672371 | 0.86 | LOXL2 (0.62) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 | |
| SCHEMBL7276383 | 0.83 | LOXL2 (0.66) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 | |
| SCHEMBL3932722 | 0.82 | LOXL2 (0.57) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 | |
| SCHEMBL31044528 | 0.82 | LOXL2 (0.57) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 | |
| SCHEMBL29539688 | 0.81 | LOXL2 (0.64) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 | |
| SCHEMBL21936783 | 0.81 | LOXL2 (0.64) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 | |
| SCHEMBL40562 | 0.81 | LOXL2 (0.64) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 | |
| SCHEMBL3816589 | 0.81 | LOXL2 (0.56) | CYP4F2CYP4A11LOXL2ALDH1A1SMN1; SMN2 | |
| SCHEMBL40066 | 0.81 | FOLH1 (0.56) | MRGPRX4SMN1; SMN2RAB9AHIF1AFOLH1 | |
| SCHEMBL31276630 | 0.80 | CYP4F2 (0.75) | CYP4F2CYP4A11LOXL2SLC7A5MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |