Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.45 |
| ▸ | RAF1 | P04049 | 4/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049622 | 0.81 | ADORA3 (0.51) | ADORA3ADORA2AADORA2BADORA1MAPK14 | |
| SCHEMBL4049130 | 0.79 | ADORA3 (0.48) | ADORA3ADORA2AADORA2BADORA1MAPK14 | |
| SCHEMBL4051165 | 0.78 | PIK3R1 (0.50) | ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL4051354 | 0.76 | ADORA2A (0.50) | ADORA3ADORA2AADORA2BADORA1MAPK14 | |
| SCHEMBL3788904 | 0.76 | ADORA2B (0.45) | ADORA2AADORA2BCSNK1A1CSNK1DRPS6KA3 | |
| SCHEMBL4059301 | 0.75 | ADORA3 (0.49) | ADORA3ADORA2AADORA2BADORA1MAPK14 | |
| SCHEMBL4054187 | 0.75 | ADORA2A (0.51) | ADORA3ADORA2AADORA2BADORA1MAPK14 | |
| SCHEMBL4051449 | 0.72 | PDE3B (0.57) | ADORA3ADORA2AADORA2BADORA1MAPK14 | |
| SCHEMBL3794512 | 0.72 | ADORA2B (0.43) | ADORA3ADORA2AADORA2BADORA1MAPK14 | |
| SCHEMBL4049728 | 0.69 | ADORA2A (0.52) | ADORA3ADORA2AADORA2BADORA1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-01-22 | — | — | US | claimed |
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-01-22 | — | — | US | disclosed |
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-01-22 | — | — | US | disclosed |
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | LABORATORIOS ALMIRALL, S.A. (ES) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023763-A1 | Condensed Pyridine Derivatives Useful as A2B Adenosine Receptor Antagonists | ADORA2B, ADORA2A, ADORA1 | ADORA3 4/4885ADORA2A 2/4885ADORA2B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.