Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 4/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | MYLK | Q15746 | 5/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051890 | 0.90 | TNKS (0.35) | TNKSTNKS2MYLKKDM4EALDH1A1 | |
| SCHEMBL4052505 | 0.85 | MYLK (0.36) | MYLK | |
| SCHEMBL4525068 | 0.82 | TNKS (0.35) | TNKSTNKS2KDM4EALDH1A1HPGD | |
| SCHEMBL4059762 | 0.81 | TNKS (0.36) | TNKSTNKS2MYLKKDM4EALDH1A1 | |
| SCHEMBL4054950 | 0.80 | KDM4E (0.32) | KDRMYLKKDM4EALDH1A1GLA | |
| SCHEMBL4062215 | 0.79 | KDR (0.34) | KDRMYLKPLK4AURKAPDPK1 | |
| SCHEMBL13693694 | 0.79 | PDE4A (0.41) | KDRMYLKKDM4EALDH1A1GLA | |
| SCHEMBL4051543 | 0.76 | KDR (0.32) | KDRMYLKSMN1; SMN2KDM4EHPGD | |
| SCHEMBL4060742 | 0.76 | HSD17B10 (0.32) | KDRMYLKKDM4EALDH1A1GLA | |
| SCHEMBL4051888 | 0.76 | MYLK (0.34) | TNKSTNKS2MYLKTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115874-A2 | NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-09-24 | — | — | WO | disclosed |