Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 9/20 | 0.42 |
| ▸ | CNR2 | P34972 | 7/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 4/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13690846 | 0.81 | HTR3A (0.46) | HTR3ACNR1CNR2CYP3A4RET | |
| SCHEMBL4049658 | 0.81 | HTR3A (0.46) | HTR3ACNR1CNR2CYP3A4RET | |
| SCHEMBL4057853 | 0.80 | HTR3A (0.45) | HTR3ACNR1CNR2CYP3A4RET | |
| SCHEMBL13691218 | 0.80 | HTR3A (0.45) | HTR3ACNR1CNR2CYP3A4RET | |
| SCHEMBL4056274 | 0.79 | HTR3A (0.46) | HTR3ACNR1CNR2CYP3A4RET | |
| SCHEMBL4056254 | 0.79 | CNR1 (0.49) | HTR3ACNR1CNR2CYP2C9RET | |
| SCHEMBL4056268 | 0.78 | RET (0.44) | HTR3ACNR1CNR2CYP3A4CFD | |
| SCHEMBL4052555 | 0.78 | CNR1 (0.47) | HTR3ACNR1CNR2CFDNR3C1 | |
| SCHEMBL13690937 | 0.76 | CNR1 (0.61) | HTR3ACNR1CNR2CYP3A4RET | |
| SCHEMBL13690904 | 0.75 | HTR3A (0.47) | HTR3ACNR1CNR2CYP3A4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |