Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1372708 | 1.00 | LMNA (0.55) | LMNAHTR3AKCNH2HRH3NOTUM | |
| SCHEMBL3946869 | 0.84 | CDK4 (0.59) | LMNANOTUMMAPTPKMCCNE2 | |
| SCHEMBL391623 | 0.81 | CDK4 (0.57) | LMNAKDM4ETDP1CCNE2CDK4 | |
| SCHEMBL15707624 | 0.81 | DRD1 (0.56) | LMNAHTR3AKDM4EDYRK1AHSD17B10 | |
| SCHEMBL8482163 | 0.81 | JAK2 (0.53) | HTR3AKCNH2HRH3MAPTKDM4E | |
| SCHEMBL1375434 | 0.80 | HTR3A (0.67) | LMNAHTR3AKCNH2HRH3KMT2A | |
| SCHEMBL3942034 | 0.78 | CDK4 (0.53) | LMNAMAPTKDM4ETDP1CCNE2 | |
| SCHEMBL3949166 | 0.78 | CDK4 (0.53) | LMNACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL2847607 | 0.77 | LMNA (0.55) | LMNAHRH3NOTUMMAPTKDM4E | |
| SCHEMBL3945127 | 0.77 | PDE4A (0.61) | LMNAMAPTKDM4ECCNE2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |