Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.57 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997923 | 0.88 | RORC (0.50) | RORCNR1H3NR1I2NR1H2CYP11B1 | |
| SCHEMBL1998534 | 0.85 | SCN2A (0.52) | RORCNR1H3NR1I2NR1H2CYP11B1 | |
| SCHEMBL2001054 | 0.82 | CNR1 (0.57) | RORCNR1H3NR1I2NR1H2CYP11B1 | |
| SCHEMBL4062546 | 0.82 | RORC (0.53) | RORCNR1H3NR1I2NR1H2CYP11B1 | |
| SCHEMBL1998946 | 0.82 | PTPN2 (0.52) | RORCNR1H3NR1I2NR1H2CYP11B1 | |
| SCHEMBL1999370 | 0.81 | CNR1 (0.57) | RORCNR1H3NR1I2NR1H2CNR1 | |
| SCHEMBL4062540 | 0.81 | RORC (0.52) | RORCNR1H3NR1I2NR1H2CYP11B1 | |
| SCHEMBL2001224 | 0.80 | NPC1 (0.48) | RORCNR1H3NR1I2NR1H2CYP11B1 | |
| SCHEMBL1999110 | 0.79 | RORC (0.54) | RORCNR1H3NR1I2NR1H2CYP11B1 | |
| SCHEMBL2001965 | 0.78 | CA2 (0.46) | RORCNR1H3NR1I2NR1H2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009035997-A2 | BENZO-FUSED HETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |