SCHEMBL4055475

SCHEMBL4055475

O=c1c2ccsc2c(-c2ccc(OCCCC3CCCNC3)cc2)nn1Cc1ccc(Cl)cc1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 12/20 0.66
NPY1R P25929 8/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4059203 0.87 HRH3 (0.64) HRH3NPY1R
SCHEMBL4066805 0.82 HRH3 (0.65) HRH3NPY1R
SCHEMBL1375439 0.80 HRH3 (1.00) HRH3
SCHEMBL1373018 0.79 HRH3 (1.00) HRH3
SCHEMBL1373020 0.79 HRH3 (1.00) HRH3
SCHEMBL4061720 0.77 HRH3 (0.64) HRH3
SCHEMBL28283793 0.74 NPY1R (0.57) NPY1R
SCHEMBL4065549 0.72 HRH3 (0.49) HRH3NPY1R
SCHEMBL4057662 0.68 HRH3 (0.61) HRH3
SCHEMBL935709 0.68 NPY1R (0.50) NPY1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2069312-A2 PYRIDIZINONE DERIVATIVES Cephalon, Inc. (US) 2009-06-17 EP claimed
WO-2008013838-A2 PYRIDIZINONE DERIVATIVES CEPHALON, INC. (US) 2008-01-31 WO claimed
EP-2069312-A2 PYRIDIZINONE DERIVATIVES Cephalon, Inc. (US) 2009-06-17 EP disclosed
WO-2008013838-A2 PYRIDIZINONE DERIVATIVES CEPHALON, INC. (US) 2008-01-31 WO disclosed