SCHEMBL4055646

SCHEMBL4055646

CN1CCN(c2cc(-c3sccc3Br)ncn2)CC1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 5/20 0.57
CYP1A2 P05177 6/20 0.53
ALDH1A1 P00352 3/20 0.52
HSD17B10 Q99714 2/20 0.52
ALOX15 P16050 2/20 0.52
CYP2C19 P33261 2/20 0.52
KDM4E B2RXH2 1/20 0.52
GLA P06280 1/20 0.52
MAPT P10636 1/20 0.52
HPGD P15428 1/20 0.52
CYP2C9 P11712 1/20 0.48
TSHR P16473 1/20 0.48
MAPK1 P28482 1/20 0.48
LRRK2 Q5S007 6/20 0.43
HRH3 Q9Y5N1 1/20 0.41
HTR3A P46098 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4063713 0.84 CYP1A2 (0.62) HRH4CYP1A2ALDH1A1HSD17B10ALOX15
SCHEMBL2385543 0.75 HRH4 (0.63) HRH4CYP1A2ALDH1A1HSD17B10ALOX15
SCHEMBL24319168 0.74 HRH4 (0.65) HRH4CYP1A2ALDH1A1HSD17B10ALOX15
SCHEMBL2384339 0.73 HRH4 (0.54) HRH4MAPTTSHRMAPK1HRH3
Hydrochloric Acid SCHEMBL11785742 0.71 HRH4 (0.97) HRH4CYP1A2ALDH1A1HSD17B10ALOX15
SCHEMBL2388209 0.71 HRH4 (0.58) HRH4CYP1A2ALDH1A1HSD17B10ALOX15
Hydrochloric Acid SCHEMBL11786310 0.69 HRH4 (0.72) HRH4CYP1A2ALDH1A1HSD17B10ALOX15
SCHEMBL2381879 0.69 HRH4 (0.50) HRH4MAPTTSHRMAPK1HRH3
SCHEMBL1775874 0.69 HRH4 (0.64) HRH4CYP1A2ALDH1A1HSD17B10ALOX15
SCHEMBL4066313 0.68 HRH4 (0.61) HRH4CYP1A2ALDH1A1HSD17B10ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009035671-A1 SUBSTITUTED NITROGEN-CONTAINING HETEROARYL DERIVATIVES USEFUL AS MODULATORS OF THE HISTAMINE H4 RECEPTOR JANSSEN PHARMACEUTICA N.V. (BE) 2009-03-19 WO claimed