Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600863 | 0.92 | KDM4E (0.46) | KDM4EPKMTGFBR1GPR119MAPT | |
| SCHEMBL4066283 | 0.92 | GPR119 (0.45) | KDM4EPKMTGFBR1GPR119MAPT | |
| SCHEMBL4055719 | 0.91 | SLC6A2 (0.49) | KDM4EPKMTGFBR1GPR119MAPT | |
| SCHEMBL4063283 | 0.90 | GPR119 (0.48) | KDM4EPKMTGFBR1GPR119MAPT | |
| SCHEMBL4056334 | 0.87 | CHRM2 (0.42) | KDM4EGPR119MAPTSMN1; SMN2 | |
| SCHEMBL4062687 | 0.86 | GPR119 (0.55) | KDM4EPKMTGFBR1GPR119LIMK2 | |
| SCHEMBL4055778 | 0.86 | GPR119 (0.43) | KDM4EPKMTGFBR1GPR119SMN1; SMN2 | |
| SCHEMBL3608780 | 0.86 | SMN1; SMN2 (0.47) | KDM4EPKMGPR119MAPTSMN1; SMN2 | |
| SCHEMBL3600866 | 0.85 | SLC6A2 (0.48) | KDM4EPKMGPR119MAPTSMN1; SMN2 | |
| SCHEMBL4066284 | 0.84 | GPR119 (0.45) | KDM4EPKMTGFBR1GPR119MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |