Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2342393 | 0.90 | MAPK14 (0.71) | MAPK14MAPTNPC1RAB9AKDM4E | |
| SCHEMBL3959437 | 0.84 | MAPT (0.58) | MAPK14MAPTNPC1RAB9AKDM4E | |
| SCHEMBL2348672 | 0.83 | MAPK14 (0.62) | MAPK14MAPTNPC1RAB9AKDM4E | |
| SCHEMBL6185626 | 0.83 | MAPK1 (0.65) | MAPTNPC1RAB9AKDM4ELMNA | |
| SCHEMBL2343083 | 0.83 | MAPK14 (0.64) | MAPK14MAPTNPC1RAB9AKDM4E | |
| SCHEMBL3952897 | 0.82 | RAF1 (0.57) | MAPK14MAPTNPC1RAB9ARAF1 | |
| SCHEMBL3955158 | 0.82 | MAPT (0.59) | MAPK14MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL5934793 | 0.82 | MAPT (0.63) | MAPTNPC1RAB9AKDM4ELMNA | |
| SCHEMBL3959184 | 0.81 | RAF1 (0.61) | MAPK14MAPTNPC1RAB9ALMNA | |
| SCHEMBL13907630 | 0.80 | MAPT (0.57) | MAPTNPC1RAB9ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034390-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C | ARROW THERAPEUTICS LIMITED (GB) | 2009-03-19 | — | — | WO | disclosed |