Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.44 |
| ▸ | VDR | P11473 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186865 | 0.81 | KDM4E (0.46) | LMNAKMT2AALDH1A1HPGD | |
| SCHEMBL4166291 | 0.80 | KCNA5 (0.59) | LMNADYRK1ACLK4RECQLCTSA | |
| SCHEMBL1965244 | 0.73 | PIN1 (0.54) | LMNADYRK1ACLK4KCNA5KMT2A | |
| SCHEMBL6856287 | 0.72 | CSNK2A2 (0.43) | RECQLVDRPPARDKMT2ARXRA | |
| SCHEMBL22160863 | 0.72 | DHODH (0.59) | LMNADYRK1ACLK4VDRKCNA5 | |
| SCHEMBL30832877 | 0.72 | DHODH (0.59) | LMNADYRK1ACLK4VDRKCNA5 | |
| SCHEMBL11248876 | 0.71 | TP53 (0.53) | LMNARECQLKMT2AMAPK1ALDH1A1 | |
| SCHEMBL4207967 | 0.71 | PTGS1 (0.59) | LMNATHRATHRBHDAC4HDAC8 | |
| SCHEMBL14983473 | 0.70 | PIK3CG (0.55) | LMNAHDAC4HDAC8DYRK1ACLK4 | |
| SCHEMBL4193609 | 0.70 | MAPK1 (0.49) | LMNAKMT2AMAPK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024371-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007134434-A1 | PHENANTHRENE DERIVATIVES AS MPGES-1 INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-11-29 | — | — | WO | disclosed |