Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3213343 | 0.87 | SIGMAR1 (0.73) | SIGMAR1ALDH1A1KCNJ1KCNH2HRH3 | |
| SCHEMBL1802599 | 0.86 | SIGMAR1 (0.71) | SIGMAR1KMT2AMEN1ALDH1A1KCNJ1 | |
| SCHEMBL30560053 | 0.86 | ALDH1A1 (0.67) | KMT2AMEN1POLBALDH1A1KCNJ1 | |
| SCHEMBL10554480 | 0.86 | SIGMAR1 (0.71) | SIGMAR1KMT2AMEN1ALDH1A1KCNJ1 | |
| SCHEMBL357155 | 0.86 | ALDH1A1 (0.67) | KMT2AMEN1POLBALDH1A1KCNJ1 | |
| SCHEMBL4572914 | 0.83 | KCNJ1 (0.70) | SIGMAR1ALDH1A1KCNJ1KCNH2HRH3 | |
| SCHEMBL12610811 | 0.83 | SIGMAR1 (0.75) | SIGMAR1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL852960 | 0.82 | KCNJ1 (0.79) | SIGMAR1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL20272175 | 0.82 | SIGMAR1 (0.79) | SIGMAR1KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL17767858 | 0.80 | SIGMAR1 (0.57) | SIGMAR1KMT2AMEN1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122180-A1 | PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES | MEDICAL RESEARCH COUNCIL (GB) | 2009-10-08 | — | — | WO | disclosed |