Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3130833 | 0.77 | ADORA2A (0.47) | ADORA2APKMTSHRCYP11B1CYP11B2 | |
| SCHEMBL15432504 | 0.73 | CYP11B1 (0.43) | ADORA2APKMMAPK14CYP11B1CYP11B2 | |
| SCHEMBL4058117 | 0.71 | CDK1 (0.38) | PKMJAK2JAK3ALDH1A1 | |
| SCHEMBL4063317 | 0.71 | CDK1 (0.34) | ADORA2AADORA1PKMCA5AJAK2 | |
| SCHEMBL4639433 | 0.69 | SMN1; SMN2 (0.36) | PKMROCK2QPCTKDM4EALDH1A1 | |
| SCHEMBL14944585 | 0.69 | CYP11B1 (0.40) | ADORA1PKMCYP11B1CYP11B2 | |
| SCHEMBL21121675 | 0.68 | ALDH1A1 (0.46) | ADORA2AADORA1PKMAXLMERTK | |
| SCHEMBL23416501 | 0.67 | ADORA2A (0.60) | ADORA2AADORA1AXLMERTKTYRO3 | |
| SCHEMBL1301644 | 0.67 | PKM (0.40) | ADORA2AADORA1PKMTSHRKDM4E | |
| SCHEMBL23416492 | 0.67 | ADORA2A (0.63) | ADORA2AADORA1AXLMERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |