Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 9/20 | 0.45 |
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNH | P51946 | 1/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058347 | 0.88 | HRH2 (0.58) | HTR6HRH2HTR2CHTR2AHTR2B | |
| SCHEMBL4055511 | 0.83 | HRH2 (0.53) | HTR6CNR1CNR2HRH2HTR2C | |
| SCHEMBL13768724 | 0.83 | HRH2 (0.57) | HTR6CNR1CNR2HRH2 | |
| SCHEMBL8316249 | 0.82 | HTR6 (0.53) | HTR6HTR2C | |
| SCHEMBL7136158 | 0.82 | HRH2 (0.49) | HTR6CNR1CNR2HRH2HTR2C | |
| SCHEMBL4053254 | 0.81 | CNR1 (0.47) | HTR6CNR1CNR2REN | |
| SCHEMBL6781286 | 0.79 | HTR6 (0.52) | HTR6CNR1CNR2HRH2HTR2C | |
| SCHEMBL5937271 | 0.78 | HTR6 (0.57) | HTR6HTR2C | |
| SCHEMBL5342259 | 0.78 | CNR2 (0.53) | HTR6CNR1CNR2 | |
| SCHEMBL5339248 | 0.78 | HRH2 (0.56) | HTR6CNR1CNR2HRH2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560471-B2 | 5-{4-[1-(2-Ethoxyethyl)-1H-indol-3-yl]piperidin-1-ylmethyl}-2-methoxybenzoic acid; histamine H1 antagonists; bronchial dialtors; asthma; allergic rhinitis; conjunctivitis; dermatitis; urticaria; selective antiallergic effects so less side effect reduction and lower dosage | LABORATORIOS ALMIRALL S.A. (ES) | 2009-07-14 | — | — | US | disclosed |
| US-7560471-B2 | 5-{4-[1-(2-Ethoxyethyl)-1H-indol-3-yl]piperidin-1-ylmethyl}-2-methoxybenzoic acid; histamine H1 antagonists; bronchial dialtors; asthma; allergic rhinitis; conjunctivitis; dermatitis; urticaria; selective antiallergic effects so less side effect reduction and lower dosage | LABORATORIOS ALMIRALL S.A. (ES) | 2009-07-14 | — | — | US | disclosed |
| US-7560471-B2 | 5-{4-[1-(2-Ethoxyethyl)-1H-indol-3-yl]piperidin-1-ylmethyl}-2-methoxybenzoic acid; histamine H1 antagonists; bronchial dialtors; asthma; allergic rhinitis; conjunctivitis; dermatitis; urticaria; selective antiallergic effects so less side effect reduction and lower dosage | LABORATORIOS ALMIRALL S.A. (ES) | 2009-07-14 | — | — | US | disclosed |
| US-20060094879-A1 | New indolylpiperidine derivatives as potent antihistaminic and antiallergic agents | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-05-04 | — | — | US | disclosed |
| EP-1513826-B1 | NEW INDOLYLPIPERIDINE DERIVATIVES AS POTENT ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094879-A1 | New indolylpiperidine derivatives as potent antihistaminic and antiallergic agents | HRH2, HRH4, HRH1 | HTR6 22/4885NPSR1 128/4885CNR1 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.