Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3864465 | 0.81 | MKNK1 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4GABRA1 | |
| SCHEMBL4048768 | 0.79 | PDE10A (0.47) | PDE10ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL15473696 | 0.78 | PDE10A (0.38) | PDE10ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL15473558 | 0.78 | PDE10A (0.43) | PDE10AGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3868180 | 0.77 | MKNK1 (0.47) | CHRNB2CHRNB4CHRNA3F2RL3F2 | |
| SCHEMBL4056285 | 0.77 | KDM1A (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4GABRA1 | |
| SCHEMBL4056288 | 0.71 | CCNT1 (0.32) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL3869784 | 0.71 | ROCK2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4GABRA1 | |
| SCHEMBL3866862 | 0.69 | MKNK1 (0.40) | PDE2ACHRM2CHRM1CYP2D6CHRM4 | |
| SCHEMBL3865957 | 0.68 | PIM1 (0.48) | CHRNB2CHRNB4CHRNA3CHRNA4GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044071-A1 | OOXO-SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINES, PRODUCTION AND USE THEREOF AS DRUGS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-04-08 | — | — | EP | claimed |
| WO-2007147646-A1 | OXO-SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINES, PRODUCTION AND USE THEREOF AS DRUGS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-27 | — | — | WO | claimed |