Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.47 |
| ▸ | ATM | Q13315 | 3/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15473558 | 0.83 | PDE10A (0.43) | PDE10AATMGABRA1GABRG2GABRB3 | |
| SCHEMBL3868180 | 0.81 | MKNK1 (0.47) | CHRNB2CHRNB4CHRNA3MEN1KMT2A | |
| SCHEMBL3870151 | 0.80 | PIM1 (0.51) | ATMGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL4056283 | 0.79 | PDE10A (0.37) | PDE10AGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL15473696 | 0.78 | PDE10A (0.38) | PDE10AATMGABRA1GABRG2GABRB3 | |
| SCHEMBL4048771 | 0.76 | GABRA1 (0.44) | ATMGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL15473971 | 0.75 | ADORA2A (0.41) | PDE10AKDM4EMAPTKMT2ANPSR1 | |
| SCHEMBL4050256 | 0.74 | PDE10A (0.41) | PDE10AKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL3865957 | 0.74 | PIM1 (0.48) | ATMGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL3869784 | 0.73 | ROCK2 (0.40) | ATMGABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044071-A1 | OOXO-SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINES, PRODUCTION AND USE THEREOF AS DRUGS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-04-08 | — | — | EP | claimed |
| WO-2007147646-A1 | OXO-SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINES, PRODUCTION AND USE THEREOF AS DRUGS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-27 | — | — | WO | claimed |