Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 9/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30891708 | 0.78 | MAPKAPK2 (0.42) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL24885835 | 0.78 | TYRO3 (0.49) | PDE3BPDE3ACA12CA9CA1 | |
| Hydrochloric Acid SCHEMBL30891705 | 0.76 | MAPKAPK2 (0.41) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL20660448 | 0.74 | HCAR1 (0.41) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL4535528 | 0.73 | CA12 (0.48) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL3334033 | 0.72 | PDE3B (0.44) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL2619211 | 0.71 | BRD4 (0.37) | CA1CA4CA6MAPK1 | |
| SCHEMBL890167 | 0.71 | NPY5R (0.37) | HTT | |
| SCHEMBL4135331 | 0.70 | CA12 (0.46) | PDE3BPDE3ACA12CA9HCAR1 | |
| SCHEMBL14494403 | 0.70 | CA12 (0.55) | PDE3BPDE3ACA12CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009112524-A1 | PYRIDOPYRIMIDINES AS PLK1 ( POLO-LIKE KINASE) INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |