Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.51 |
| ▸ | BCHE | P06276 | 3/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056779 | 0.84 | HRH3 (0.66) | HRH3KCNH2CACNA1FBCHECACNA1D | |
| SCHEMBL1375239 | 0.83 | HRH3 (0.64) | HRH3KCNH2CACNA1FBCHECACNA1D | |
| SCHEMBL4224568 | 0.77 | HRH3 (0.93) | HRH3KCNH2CACNA1FBCHECACNA1D | |
| SCHEMBL22609290 | 0.75 | ALDH1A1 (0.47) | MAPTKDM4EALDH1A1 | |
| SCHEMBL22609305 | 0.74 | TARBP2 (0.51) | CACNA1FCACNA1DCACNA1SCACNA1CMAPT | |
| SCHEMBL22609228 | 0.74 | HTT (0.48) | MAPTKDM4EALDH1A1 | |
| SCHEMBL4096430 | 0.74 | HRH3 (1.00) | HRH3KCNH2KDM4EALDH1A1 | |
| SCHEMBL2820780 | 0.73 | HRH3 (0.69) | HRH3KCNH2POLBMAPTKDM4E | |
| SCHEMBL491935 | 0.72 | HRH3 (0.88) | HRH3 | |
| Hydrochloric Acid SCHEMBL9061899 | 0.71 | HRH3 (0.86) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |