Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.66 |
| ▸ | MLYCD | O95822 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 5/20 | 0.50 |
| ▸ | HRH1 | P35367 | 5/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.50 |
| ▸ | BCHE | P06276 | 3/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375239 | 0.85 | HRH3 (0.64) | HRH3KCNH2HRH2HRH1CACNA1F | |
| SCHEMBL4056777 | 0.84 | HRH3 (0.58) | HRH3KCNH2CACNA1FBCHECACNA1D | |
| SCHEMBL4096430 | 0.80 | HRH3 (1.00) | HRH3KCNH2HRH2HRH1KDM4E | |
| SCHEMBL4224568 | 0.78 | HRH3 (0.93) | HRH3KCNH2HRH2HRH1CACNA1F | |
| SCHEMBL435212 | 0.74 | MLYCD (0.67) | MLYCDALDH1A1 | |
| SCHEMBL4090529 | 0.73 | HRH3 (0.67) | HRH3KCNH2HRH2HRH1BCHE | |
| SCHEMBL4090531 | 0.73 | HRH3 (0.67) | HRH3KCNH2HRH2HRH1BCHE | |
| SCHEMBL228881 | 0.72 | KCNH2 (0.81) | HRH3KCNH2HRH2HRH1MAPT | |
| SCHEMBL223800 | 0.72 | KCNH2 (0.81) | HRH3KCNH2HRH2HRH1MAPT | |
| SCHEMBL2212118 | 0.71 | HRH3 (0.71) | HRH3KCNH2CACNA1FBCHECACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |