Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ACP1 | P24666 | 2/20 | 0.44 |
| ▸ | NPY1R | P25929 | 7/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055751 | 0.88 | HRH3 (0.46) | HRH3KCNH2ACP1NPY1RSYK | |
| SCHEMBL4054814 | 0.87 | HRH3 (0.58) | HRH3KCNH2 | |
| SCHEMBL4065549 | 0.85 | HRH3 (0.49) | HRH3ACP1NPY1RBRD4 | |
| SCHEMBL4055627 | 0.85 | ACP1 (0.42) | HRH3KCNH2ACP1NPY1RBRD4 | |
| SCHEMBL4060869 | 0.83 | HTR3A (0.60) | HRH3KCNH2NPY1RHTR3A | |
| SCHEMBL4057615 | 0.82 | HRH3 (0.59) | HRH3KCNH2ACP1NPY1RSYK | |
| SCHEMBL4059363 | 0.80 | HTR3A (0.59) | HRH3KCNH2ACP1NPY1RHTR3A | |
| SCHEMBL4060149 | 0.79 | HRH3 (0.59) | HRH3KCNH2ACP1HTR3A | |
| SCHEMBL4056854 | 0.78 | HTR3A (0.46) | HRH3ACP1NPY1RHTR3A | |
| SCHEMBL4057349 | 0.78 | HTR3A (0.58) | HRH3KCNH2NPY1RHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | claimed |
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |