Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 11/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059363 | 0.97 | HTR3A (0.59) | HTR3AHRH3KCNH2TLR7NPY1R | |
| SCHEMBL4059525 | 0.83 | HTR3A (0.61) | HTR3AHRH3NPY1R | |
| SCHEMBL4066338 | 0.80 | HTR3A (0.62) | HTR3AHRH3NPY1R | |
| SCHEMBL4060869 | 0.80 | HTR3A (0.60) | HTR3AHRH3KCNH2TLR7NPY1R | |
| SCHEMBL4057964 | 0.78 | MAP2K1 (0.42) | HTR3ATLR7NPY1R | |
| SCHEMBL4054814 | 0.78 | HRH3 (0.58) | HRH3KCNH2 | |
| SCHEMBL4056938 | 0.78 | HRH3 (0.44) | HTR3AHRH3KCNH2NPY1R | |
| SCHEMBL4056854 | 0.77 | HTR3A (0.46) | HTR3AHRH3TLR7NPY1R | |
| SCHEMBL4057662 | 0.76 | HRH3 (0.61) | HRH3HPGD | |
| SCHEMBL4061696 | 0.75 | HRH3 (0.50) | HTR3AHRH3TLR7NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |