Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275027 | 0.87 | TSHR (0.53) | TSHRMAPK10SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL15286510 | 0.87 | ALDH1A1 (0.51) | TSHRMAPK10SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL7275470 | 0.86 | TSHR (0.51) | TSHRMAPK10SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL7274960 | 0.86 | TSHR (0.51) | TSHRMAPK10SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL4415159 | 0.85 | TSHR (0.50) | TSHRMAPK10SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL10565150 | 0.84 | TSHR (0.49) | TSHRMAPK10SMN1; SMN2HSD17B10ALDH1A1 | |
| Methane SCHEMBL10565161 | 0.84 | TSHR (0.49) | TSHRMAPK10SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL5988399 | 0.83 | TP53 (0.56) | ALDH1A1NPC1HTTMAOBFFAR1 | |
| SCHEMBL10566401 | 0.83 | TSHR (0.48) | TSHRMAPK10SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL4417759 | 0.83 | ALDH1A1 (0.48) | TSHRMAPK10SMN1; SMN2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009109999-A1 | NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS | LUPIN LIMITED (IN) | 2009-09-11 | — | — | WO | disclosed |