SCHEMBL4057221

SCHEMBL4057221

CC(C)OC(=O)N1CCC(N(C)Cc2cnc(-c3ccc(C(N)=O)c(F)c3)cn2)CC1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 17/20 0.53
ATR Q13535 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4058199 0.92 GPR119 (0.51) GPR119
SCHEMBL4049265 0.88 GPR119 (0.52) GPR119
SCHEMBL4050169 0.86 GPR119 (0.57) GPR119
SCHEMBL4376355 0.86 ATR (0.39) GPR119ATR
SCHEMBL13690548 0.82 JAK2 (0.44) ATR
SCHEMBL13690504 0.81 GPR119 (0.53) GPR119
SCHEMBL4048482 0.80 GPR119 (0.56) GPR119
SCHEMBL4047813 0.80 GPR119 (0.52) GPR119
SCHEMBL13690401 0.80 GPR119 (0.48) GPR119ATR
SCHEMBL13690402 0.79 GPR119 (0.46) GPR119ATR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009106561-A1 PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS BIOVITRUM AB (PUBL) (SE) 2009-09-03 WO disclosed
WO-2009106561-A1 PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS BIOVITRUM AB (PUBL) (SE) 2009-09-03 WO disclosed