Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18726996 | 0.81 | HDAC1 (0.47) | HDAC1NPC1POLBGAAGFER | |
| SCHEMBL434154 | 0.80 | SMN1; SMN2 (0.61) | HDAC1NPC1POLBGAAGFER | |
| Hydrochloric Acid SCHEMBL6544490 | 0.78 | SMN1; SMN2 (0.59) | HDAC1NPC1POLBGAAGFER | |
| SCHEMBL15004605 | 0.77 | HDAC1 (0.47) | HDAC1NPC1POLBGAAGFER | |
| SCHEMBL1426603 | 0.77 | HDAC1 (0.50) | HDAC1NPC1POLBGAAGFER | |
| SCHEMBL16212792 | 0.77 | TLR9 (0.53) | HDAC1NPC1POLBGAAGFER | |
| SCHEMBL15004606 | 0.77 | HDAC1 (0.47) | HDAC1NPC1POLBGAAGFER | |
| SCHEMBL13050352 | 0.77 | TP53 (0.38) | HDAC1NPC1POLBGAAGFER | |
| SCHEMBL13080648 | 0.77 | KDM4E (0.48) | NPC1POLBGAAGFERKMT2A | |
| SCHEMBL20599405 | 0.77 | HDAC1 (0.47) | HDAC1NPC1POLBGAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240327412-A1 | FACTOR XIIA INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2024-10-03 | — | — | US | disclosed |
| EP-4294798-A1 | FACTOR XIIA INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2023-12-27 | — | — | EP | disclosed |
| WO-2022221227-A9 | AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS | NUVALENT, INC. (US) | 2023-11-30 | — | — | WO | disclosed |
| CN-116829547-A | Factor XIIa inhibitors | 卡尔维斯塔制药有限公司 | 2023-09-29 | — | — | CN | disclosed |
| WO-2022175675-A1 | FACTOR XIIA INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2022-08-25 | — | — | WO | disclosed |
| US-20210371433-A1 | Novel Monocyclic And Bicyclic Ring System Substituted Carbanucleoside Analogues For Use As PRMT5 Inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-12-02 | — | — | US | disclosed |
| WO-2021179274-A1 | ErbB RECEPTOR INHIBITORS AS ANTI-TUMOR AGENTS | SUZHOU ZANRONG PHARMA LTD. (CN) | 2021-09-16 | — | — | WO | disclosed |
| US-20190263833-A1 | NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-08-29 | — | — | US | disclosed |
| WO-2018065365-A1 | NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |
| US-20150322069-A1 | PHENOXYMETHYL HETEROCYCLIC COMPOUNDS | FMR LLC | 2015-11-12 | — | — | US | disclosed |
| US-8946222-B2 | Phenoxymethyl heterocyclic compounds | FORUM PHARMACEUTICALS INC. (US) | 2015-02-03 | — | — | US | disclosed |
| US-20130143888-A1 | PHENOXYMETHYL HETEROCYCLIC COMPOUNDS | ENVIVO PHAMACEUTICALS, INC. (US) | 2013-06-06 | — | — | US | disclosed |
| EP-2041153-B1 | NEW 5-THIOXYLOPYRANOSE DERIVATIVES | FOURNIER LAB SA (FR) | 2009-10-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263833-A1 | NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT8 | HDAC1 39/4885NPC1 2629/4885POLB 1648/4885 |
| US-20210371433-A1 | Novel Monocyclic And Bicyclic Ring System Substituted Carbanucleoside Analogues For Use As PRMT5 Inhibitors | PRMT5, PRMT1, PRMT8 | HDAC1 46/4885NPC1 2590/4885POLB 1637/4885 |
| US-20150322069-A1 | PHENOXYMETHYL HETEROCYCLIC COMPOUNDS | PDE3A, PDE2A, PDE5A | HDAC1 131/4885NPC1 2094/4885POLB 1728/4885 |
| US-20240327412-A1 | FACTOR XIIA INHIBITORS | F11, F13B, F12 | HDAC1 345/4885NPC1 3064/4885POLB 1691/4885 |
| US-20130143888-A1 | PHENOXYMETHYL HETEROCYCLIC COMPOUNDS | PDE3A, PDE2A, PDE5A | HDAC1 131/4885NPC1 2094/4885POLB 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.