Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.69 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 5/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055755 | 0.93 | TRPV4 (0.80) | TRPV4TAS1R3TAS1R1CTSKPIN1 | |
| SCHEMBL19856867 | 0.93 | TRPV4 (0.80) | TRPV4TAS1R3TAS1R1CTSKPIN1 | |
| SCHEMBL4054373 | 0.93 | TRPV4 (0.80) | TRPV4TAS1R3TAS1R1CTSKPIN1 | |
| SCHEMBL4056670 | 0.93 | TRPV4 (0.80) | TRPV4TAS1R3TAS1R1CTSKPIN1 | |
| SCHEMBL4049808 | 0.92 | TRPV4 (0.70) | TRPV4TAS1R3TAS1R1CTSKPIN1 | |
| SCHEMBL4056819 | 0.92 | TRPV4 (0.69) | TRPV4TAS1R3TAS1R1CTSKPIN1 | |
| SCHEMBL4050801 | 0.91 | TRPV4 (0.68) | TRPV4TAS1R3TAS1R1CTSKPIN1 | |
| SCHEMBL4050161 | 0.90 | TRPV4 (0.56) | TRPV4PSMB5PIN1CCR1CTSB | |
| SCHEMBL4049701 | 0.89 | TRPV4 (0.65) | TRPV4TAS1R3TAS1R1CTSKPIN1 | |
| SCHEMBL4051481 | 0.88 | TRPV4 (0.64) | TRPV4TAS1R3TAS1R1CTSKPIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |