Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.80 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 6/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056670 | 1.00 | TRPV4 (0.80) | TRPV4TAS1R3TAS1R1CTSKCCR1 | |
| SCHEMBL4054373 | 1.00 | TRPV4 (0.80) | TRPV4TAS1R3TAS1R1CTSKCCR1 | |
| SCHEMBL4055755 | 1.00 | TRPV4 (0.80) | TRPV4TAS1R3TAS1R1CTSKCCR1 | |
| SCHEMBL4049808 | 0.94 | TRPV4 (0.70) | TRPV4TAS1R3TAS1R1CTSKCCR1 | |
| SCHEMBL4058684 | 0.93 | TRPV4 (0.69) | TRPV4TAS1R3TAS1R1CTSKCCR1 | |
| SCHEMBL4056819 | 0.93 | TRPV4 (0.69) | TRPV4TAS1R3TAS1R1CTSKCCR1 | |
| SCHEMBL4050801 | 0.92 | TRPV4 (0.68) | TRPV4TAS1R3TAS1R1CTSKCCR1 | |
| SCHEMBL4049701 | 0.90 | TRPV4 (0.65) | TRPV4TAS1R3TAS1R1CTSKCCR1 | |
| SCHEMBL4053125 | 0.90 | TRPV4 (0.65) | TRPV4TAS1R3TAS1R1CTSKCCR1 | |
| SCHEMBL4051481 | 0.89 | TRPV4 (0.64) | TRPV4TAS1R3TAS1R1CTSKCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |