Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 10/20 | 0.61 |
| ▸ | CNR2 | P34972 | 6/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.41 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13691222 | 1.00 | CNR1 (0.61) | CNR1CNR2ROCK1GUCY1A1GUCY1B1 | |
| SCHEMBL13690929 | 0.88 | CNR1 (0.75) | CNR1CNR2ROCK1ALDH1A1HTR3A | |
| SCHEMBL4053063 | 0.86 | CNR1 (0.77) | CNR1CNR2HTR3AKDM4E | |
| SCHEMBL30473233 | 0.86 | CNR1 (0.77) | CNR1CNR2HTR3AKDM4E | |
| SCHEMBL29993194 | 0.86 | CNR1 (0.77) | CNR1CNR2HTR3AKDM4E | |
| SCHEMBL4052282 | 0.85 | CNR1 (0.54) | CNR1CNR2ROCK1GUCY1A1GUCY1B1 | |
| SCHEMBL4050831 | 0.84 | CNR1 (0.64) | CNR1CNR2ROCK1HTR3A | |
| SCHEMBL13691230 | 0.84 | CNR1 (0.61) | CNR1CNR2ROCK1HTR3A | |
| SCHEMBL4055963 | 0.84 | CNR1 (0.61) | CNR1CNR2ROCK1HTR3A | |
| SCHEMBL4056691 | 0.83 | CNR1 (0.61) | CNR1CNR2ROCK1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | claimed |
| WO-2009106980-A2 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |