Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.62 |
| ▸ | CCR2 | P41597 | 4/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.56 |
| ▸ | NOS2 | P35228 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2267177 | 0.86 | HSD11B1 (0.63) | HSD11B1OPRL1OPRM1OPRK1 | |
| SCHEMBL16801704 | 0.85 | KDM4E (0.65) | HSD11B1CCR2OPRL1OPRM1OPRK1 | |
| SCHEMBL6158491 | 0.83 | HSD11B1 (0.66) | HSD11B1CCR2OPRL1OPRM1OPRK1 | |
| SCHEMBL4055416 | 0.81 | ALDH1A1 (0.71) | HSD11B1CCR2ALDH1A1KMT2A | |
| SCHEMBL13090626 | 0.81 | HSD11B1 (0.72) | HSD11B1CCR2OPRL1OPRM1OPRK1 | |
| SCHEMBL4056419 | 0.80 | HSD11B1 (0.54) | HSD11B1CCR2NOS2CHRM4MEN1 | |
| SCHEMBL20780007 | 0.80 | HTT (0.55) | HSD11B1CCR2OPRL1OPRM1OPRK1 | |
| SCHEMBL12509445 | 0.80 | HSD11B1 (0.69) | HSD11B1OPRL1OPRM1OPRK1 | |
| SCHEMBL23722557 | 0.80 | HSD11B1 (0.59) | HSD11B1CCR2OPRL1OPRM1OPRK1 | |
| SCHEMBL14280711 | 0.79 | OPRL1 (0.64) | HSD11B1CCR2OPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7622480-B2 | Selective H1 histamine receptor antagonists; bronchial asthma, allergic rhinitis, conjunctivitis, dermatitis, urticaria and other allergic diseases; e.g. 3-(4-[1-(2-methoxyethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]piperidin-1-ylmethyl)benzoic acid | LABORATORIOS ALMIRALL S.A. (ES) | 2009-11-24 | — | — | US | disclosed |
| EP-1497292-B1 | AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA SA (ES) | 2006-06-14 | — | — | EP | disclosed |
| US-20050176751-A1 | Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-08-11 | — | — | US | disclosed |
| EP-1497292-A1 | AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003082867-A1 | AZAINDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA S.A. (ES) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176751-A1 | Azaindolylpiperidine derivatives as antihistaminic and antiallergic agents | HRH2, HRH1, HRH4 | HSD11B1 2048/4885CCR2 2521/4885OPRL1 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.