Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048715 | 0.73 | METAP1 (0.58) | METAP2METAP1 | |
| SCHEMBL3949357 | 0.70 | DAO (0.37) | — | |
| SCHEMBL4046146 | 0.69 | METAP2 (0.64) | METAP2METAP1 | |
| SCHEMBL3951853 | 0.68 | ROCK2 (0.35) | — | |
| SCHEMBL3953388 | 0.67 | SYK (0.32) | — | |
| SCHEMBL3950079 | 0.67 | CCNB2 (0.31) | — | |
| SCHEMBL10735823 | 0.67 | METAP2 (0.51) | METAP2METAP1 | |
| SCHEMBL10737047 | 0.67 | METAP2 (0.51) | METAP2METAP1EGLN1 | |
| SCHEMBL10740734 | 0.65 | PDE5A (0.65) | METAP2METAP1 | |
| SCHEMBL10742556 | 0.65 | METAP2 (0.57) | METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009029592-A1 | HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |
| WO-2008103615-A1 | ISOQUINOLINES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2008-08-28 | — | — | WO | disclosed |