Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.69 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | USP14 | P54578 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059111 | 0.90 | HTT (0.67) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4066324 | 0.88 | CLK1 (0.69) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4066988 | 0.82 | HTT (1.00) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4062708 | 0.75 | CLK1 (0.93) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4060137 | 0.73 | MAPT (0.82) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4071064 | 0.72 | HTT (0.81) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4065608 | 0.72 | HTT (1.00) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4795234 | 0.72 | CLK1 (0.85) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL30697294 | 0.71 | CLK1 (1.00) | HTTCLK1GSK3BDYRK1ACLK4 | |
| SCHEMBL4063265 | 0.71 | CLK1 (1.00) | HTTCLK1GSK3BDYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960777-B1 | SERUM-FREE EXPANSION OF CELLS IN CULTURE | CHOONGWAE PHARMA CORP (KR) | 2009-10-21 | — | — | EP | disclosed |
| US-20070128669-A1 | Serum-free expansion of cells in culture | INSTITUTE FOR CHEMICAL GENOMICS (US) | 2007-06-07 | — | — | US | disclosed |