Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 3/20 | 0.56 |
| ▸ | ULK2 | Q8IYT8 | 3/20 | 0.56 |
| ▸ | TBK1 | Q9UHD2 | 14/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.55 |
| ▸ | MARK3 | P27448 | 4/20 | 0.55 |
| ▸ | MARK4 | Q96L34 | 3/20 | 0.55 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.55 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.55 |
| ▸ | SIK1 | P57059 | 1/20 | 0.55 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.55 |
| ▸ | MELK | Q14680 | 1/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.55 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.55 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.55 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.55 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.55 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388328 | 0.89 | TBK1 (0.54) | ULK1ULK2TBK1IKBKENTRK1 | |
| SCHEMBL3385829 | 0.85 | ULK2 (0.75) | ULK1ULK2TBK1IKBKENTRK1 | |
| SCHEMBL4066088 | 0.84 | ULK1 (0.64) | ULK1ULK2TBK1IKBKENTRK1 | |
| SCHEMBL4060196 | 0.83 | ULK1 (0.58) | ULK1ULK2TBK1IKBKENTRK1 | |
| SCHEMBL3389420 | 0.83 | TBK1 (0.72) | ULK1ULK2TBK1IKBKENTRK1 | |
| SCHEMBL3389002 | 0.82 | ULK1 (0.57) | ULK1ULK2TBK1IKBKENTRK1 | |
| SCHEMBL3388281 | 0.82 | MAP3K7 (0.56) | ULK1ULK2TBK1IKBKENTRK1 | |
| SCHEMBL3384461 | 0.81 | TBK1 (0.54) | ULK1ULK2TBK1IKBKENTRK1 | |
| SCHEMBL3386107 | 0.79 | TBK1 (0.56) | ULK1ULK2TBK1IKBKENTRK1 | |
| Trifluoroacetic Acid SCHEMBL3387959 | 0.79 | TBK1 (0.66) | ULK1ULK2TBK1IKBKENTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009122180-A1 | PYRIMIDINE DERIVATIVES CAPABLE OF INHIBITING ONE OR MORE KINASES | MEDICAL RESEARCH COUNCIL (GB) | 2009-10-08 | — | — | WO | disclosed |