Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.45 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 7/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056596 | 0.88 | PDE4A (0.56) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4065947 | 0.84 | HRH3 (0.56) | HRH3ACP1CHRM2SLC6A2ADRA1A | |
| SCHEMBL4057147 | 0.84 | HRH3 (0.56) | HRH3ACP1CHRM2SLC6A2ADRA1A | |
| SCHEMBL4056306 | 0.79 | HRH3 (0.46) | HRH3FFAR4ACP1TLR9TLR8 | |
| SCHEMBL4055633 | 0.78 | PDE3B (0.43) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4055490 | 0.77 | HRH3 (0.56) | HRH3PDE4BCHRM2SLC6A2ADRA1A | |
| SCHEMBL10259128 | 0.76 | HRH3 (0.69) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4061241 | 0.75 | HRH3 (0.48) | HRH3ACP1CHRM2SLC6A2ADRA1A | |
| SCHEMBL1374866 | 0.75 | HRH3 (0.69) | HRH3PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1376722 | 0.74 | HRH3 (0.79) | HRH3CHRM2SLC6A2ADRA1AHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | claimed |
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |