Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACP1 | P24666 | 7/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4060210 | 0.78 | HRH3 (0.45) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL1373424 | 0.76 | HRH3 (0.72) | HRH3 | |
| SCHEMBL1373427 | 0.76 | HRH3 (0.72) | HRH3 | |
| SCHEMBL1375275 | 0.75 | HRH3 (0.68) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL4056306 | 0.73 | HRH3 (0.46) | HRH3TLR9TLR8TLR7ACP1 | |
| SCHEMBL2846170 | 0.71 | PDE3B (0.77) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL27754059 | 0.70 | LMNA (0.47) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL4065277 | 0.69 | HRH3 (0.62) | PDE3BPDE3APDE4BPDE4APDE4C | |
| SCHEMBL6640628 | 0.69 | NPY1R (0.41) | NPY1RHRH3KMT2AACP1 | |
| SCHEMBL4903296 | 0.69 | PDE3B (0.54) | PDE3BPDE3APDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069312-A2 | PYRIDIZINONE DERIVATIVES | Cephalon, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013838-A2 | PYRIDIZINONE DERIVATIVES | CEPHALON, INC. (US) | 2008-01-31 | — | — | WO | disclosed |