Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536762 | 0.85 | HTR2C (0.44) | HTR2CEPHX2KDM4EALDH1A1 | |
| SCHEMBL31736542 | 0.85 | HTR2C (0.44) | HTR2CEPHX2KDM4EALDH1A1 | |
| SCHEMBL28145053 | 0.84 | SIRT2 (0.43) | PIM1PIM3KDM4EALDH1A1 | |
| SCHEMBL5754262 | 0.83 | SIRT2 (0.46) | PIM1PIM3KDM4EALDH1A1 | |
| SCHEMBL29546527 | 0.83 | SIRT2 (0.46) | PIM1PIM3KDM4EALDH1A1 | |
| SCHEMBL15733283 | 0.80 | AURKA (0.47) | KDM4E | |
| SCHEMBL31687675 | 0.80 | MEN1 (0.42) | ALDH1A1 | |
| SCHEMBL2351827 | 0.79 | CHRNB2 (0.41) | HTR2CCHRNB2CHRNA4 | |
| SCHEMBL13116668 | 0.78 | HTR2C (0.56) | HTR2CEPHX2KDM4EALDH1A1 | |
| SCHEMBL4805575 | 0.77 | EPHX2 (0.40) | HTR2CPIM1PIM3EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079756-A2 | SYNTHETIC PEPTIDE AMIDES AND DIMERS THEREOF | Cara Therapeutics, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008060552-A2 | SYNTHETIC PEPTIDE AMIDES AND DIMERS THEREOF | CARA THERAPEUTICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |