Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | PDE2A | O00408 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | BCDIN3D | Q7Z5W3 | 5/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947360 | 0.91 | TP53 (0.62) | KMT2AMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL13943740 | 0.86 | HTR2C (0.66) | KMT2AMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL13942975 | 0.84 | HTR2C (0.71) | KMT2AMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL3949781 | 0.84 | HTR2C (0.66) | KMT2AMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL13942981 | 0.84 | HTR2C (0.74) | KMT2AMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL13947363 | 0.84 | PDE2A (0.75) | KMT2AMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL13942968 | 0.83 | HTR2C (0.70) | KMT2AMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL4053549 | 0.82 | KMT2A (0.66) | KMT2AMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL13947562 | 0.82 | PDE2A (0.77) | KMT2AMAPTKDM4EALDH1A1NPSR1 | |
| SCHEMBL13947205 | 0.82 | SHMT2 (0.67) | KMT2AMAPTKDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | claimed |
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |