SCHEMBL4062196

SCHEMBL4062196

N#Cc1cccnc1CCO

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.41
L3MBTL1 Q9Y468 4/20 0.41
HPGD P15428 6/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP3A4 P08684 1/20 0.39
LRRK2 Q5S007 1/20 0.39
NPC1 O15118 4/20 0.38
RAB9A P51151 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
TDP1 Q9NUW8 1/20 0.38
CASP3 P42574 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
KDM4E B2RXH2 4/20 0.37
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20099837 0.89 CXCR4 (0.46) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6
SCHEMBL25198363 0.85 ALDH1A1 (0.53) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6
SCHEMBL30496159 0.85 ALDH1A1 (0.53) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6
SCHEMBL7213726 0.81 HPGD (0.49) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6
SCHEMBL27933237 0.81 HPGD (0.39) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6
SCHEMBL11370703 0.79 KDM4E (0.56) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6
SCHEMBL7219978 0.79 HPGD (0.56) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6
SCHEMBL18424317 0.78 KDM4E (0.43) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6
SCHEMBL11385992 0.77 HPGD (0.46) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6
SCHEMBL3313973 0.77 HPGD (0.51) ALDH1A1L3MBTL1HPGDCYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022155419-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS ESCAPE Bio, Inc. (US) 2022-07-21 WO disclosed
EP-1706412-A4 NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SK CHEMICALS CO LTD (KR) 2009-03-18 EP disclosed
EP-1706412-A1 NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SK Chemicals, Co., Ltd. (KR) 2006-10-04 EP disclosed
WO-2005063768-A1 NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME SK CHEMICALS, CO., LTD. (KR) 2005-07-14 WO disclosed