Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 4/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189000 | 0.85 | HRH3 (0.34) | HRH3METSPR | |
| SCHEMBL4206238 | 0.80 | VNN1 (0.36) | VNN1HRH3SPRF10SYK | |
| SCHEMBL208583 | 0.79 | MET (0.36) | HRH3METSPRRORCP2RX7 | |
| SCHEMBL208582 | 0.79 | MET (0.36) | HRH3METSPRRORCP2RX7 | |
| SCHEMBL209140 | 0.79 | MET (0.36) | HRH3METSPRRORCP2RX7 | |
| SCHEMBL208581 | 0.79 | MET (0.36) | HRH3METSPRRORCP2RX7 | |
| SCHEMBL4058807 | 0.77 | NPSR1 (0.35) | VNN1HRH3SPR | |
| SCHEMBL4179199 | 0.75 | PDE5A (0.34) | HRH3MET | |
| SCHEMBL1091982 | 0.74 | HTR2B (0.34) | HRH3METSPRP2RX7 | |
| SCHEMBL1091979 | 0.74 | HTR2B (0.34) | HRH3METSPRP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016047-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007124337-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |