Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | BUB1 | O43683 | 3/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20298987 | 0.77 | KMT2A (0.52) | GRM5KDRABCG2LMNAEGFR | |
| SCHEMBL375687 | 0.75 | PDE4B (0.44) | GRM5KDRABCG2LMNAEGFR | |
| SCHEMBL4063171 | 0.73 | KDR (0.40) | GRM5KDRABCG2LMNAEGFR | |
| SCHEMBL20299032 | 0.70 | ABCG2 (0.68) | ABCG2TAAR1LMNAKDM4EEGFR | |
| SCHEMBL29019911 | 0.69 | CTSC (0.52) | KDRJAK2ABCG2EGFR | |
| SCHEMBL30394423 | 0.69 | CTSC (0.52) | KDRJAK2ABCG2EGFR | |
| SCHEMBL2874930 | 0.69 | NFKB1 (0.65) | TAAR1LMNAKDM4ENPC1RAB9A | |
| SCHEMBL20319866 | 0.68 | MKNK1 (0.55) | HTR1ADRD2HTR2AHTR2CHTR7 | |
| SCHEMBL22606145 | 0.67 | KDR (0.47) | KDRJAK2ABCG2TAAR1LMNA | |
| SCHEMBL2995233 | 0.67 | BRAF (0.51) | KDRJAK2ABCG2EGFRFADS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108534-A1 | Dihydrothienopyrimidines for the treatment of inflammatory Diseases | POUZET PASCALE (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108534-A1 | Dihydrothienopyrimidines for the treatment of inflammatory Diseases | POUZET PASCALE (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108534-A1 | Dihydrothienopyrimidines for the treatment of inflammatory Diseases | DPYD, DHFR, TPMT | GRM5 1336/4885KDR 1604/4885BUB1 2002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.