Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4056816 | 0.92 | MEN1 (0.51) | MEN1KMT2AAVPR1ATP53ALOX15 | |
| SCHEMBL4062349 | 0.90 | MGLL (0.41) | MEN1KMT2AAVPR1ARXFP1TPSAB1 | |
| SCHEMBL28771302 | 0.86 | AVPR1A (0.41) | MEN1KMT2AAVPR1ATP53CNR1 | |
| SCHEMBL4058086 | 0.85 | KMT2A (0.40) | MEN1KMT2AAVPR1ARXFP1LMNA | |
| SCHEMBL28771298 | 0.83 | AVPR1A (0.42) | MEN1KMT2AAVPR1ATP53CNR1 | |
| SCHEMBL4057822 | 0.82 | AVPR1A (0.40) | MEN1KMT2AAVPR1ARXFP1LMNA | |
| SCHEMBL614916 | 0.81 | AVPR1A (0.56) | MEN1KMT2AAVPR1ACNR1ALDH1A1 | |
| SCHEMBL4629615 | 0.78 | MAPT (0.47) | MEN1KMT2ALMNATSHRMAPT | |
| SCHEMBL615187 | 0.77 | AVPR1A (0.55) | MEN1KMT2AAVPR1ACNR1TPSAB1 | |
| SCHEMBL27736975 | 0.76 | AVPR1A (0.40) | MEN1KMT2AAVPR1ACNR1TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009502859-A | — | — | 2009-01-29 | — | — | JP | claimed |
| EP-1917255-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-05-07 | — | — | EP | claimed |
| WO-2007014851-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | claimed |
| EP-1917255-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007014851-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |