Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL615572 | 0.82 | AVPR1A (0.59) | MAPTSMN1; SMN2NPSR1LMNATSHR | |
| SCHEMBL4056816 | 0.79 | MEN1 (0.51) | MAPTNPSR1TSHRKMT2AMEN1 | |
| SCHEMBL4058086 | 0.78 | KMT2A (0.40) | MAPTLMNATSHRKMT2AMEN1 | |
| SCHEMBL614542 | 0.78 | MAPT (0.53) | MAPTSMN1; SMN2NPSR1LMNATSHR | |
| SCHEMBL4063136 | 0.78 | MEN1 (0.41) | MAPTNPSR1LMNATSHRKMT2A | |
| SCHEMBL614946 | 0.78 | AVPR1A (0.57) | MAPTSMN1; SMN2NPSR1LMNATSHR | |
| SCHEMBL613491 | 0.78 | MAPT (0.53) | MAPTSMN1; SMN2NPSR1LMNATSHR | |
| SCHEMBL4062349 | 0.77 | MGLL (0.41) | KMT2AMEN1 | |
| SCHEMBL613064 | 0.77 | AVPR1A (0.58) | MAPTSMN1; SMN2NPSR1LMNATSHR | |
| SCHEMBL28775553 | 0.73 | AVPR1A (0.46) | MAPTSMN1; SMN2TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917255-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007014851-A2 | INDOL-3-YL-CARBONYL-PIPERIDIN AND PIPERAZIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |