Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062687 | 0.95 | GPR119 (0.55) | GPR119KDM4EPKMLIMK2TGFBR1 | |
| SCHEMBL4063156 | 0.90 | GPR119 (0.51) | GPR119KDM4EPKM | |
| SCHEMBL4059665 | 0.90 | GPR119 (0.53) | GPR119KDM4EPKMLIMK2TGFBR1 | |
| SCHEMBL3600088 | 0.87 | CHRM2 (0.46) | GPR119 | |
| SCHEMBL4062683 | 0.85 | GPR119 (0.55) | GPR119KDM4EPKM | |
| SCHEMBL3605057 | 0.85 | HTR6 (0.47) | GPR119 | |
| SCHEMBL4058427 | 0.85 | GPR119 (0.46) | GPR119KDM4EPKMTP53THRB | |
| SCHEMBL3605457 | 0.83 | CHRM2 (0.43) | GPR119 | |
| SCHEMBL3600863 | 0.83 | KDM4E (0.46) | GPR119KDM4EPKMLIMK2TGFBR1 | |
| SCHEMBL4063283 | 0.83 | GPR119 (0.48) | GPR119KDM4EPKMLIMK2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061776-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | Wyeth a Corporation of the State of Delaware (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008073459-A1 | ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |