Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 4/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | PLAU | P00749 | 2/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | PLG | P00747 | 1/20 | 0.62 |
| ▸ | PLAT | P00750 | 1/20 | 0.62 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.62 |
| ▸ | KLK1 | P06870 | 1/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.62 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.59 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24891830 | 0.93 | KMT2A (0.64) | PTPN1MEN1KMT2APOLBKDM4E | |
| SCHEMBL9303338 | 0.87 | F2 (0.67) | MEN1KMT2APOLBPLAUF2 | |
| SCHEMBL9029819 | 0.87 | PLAU (0.73) | PTPN1MEN1KMT2APOLBHDAC2 | |
| SCHEMBL14715847 | 0.87 | PTPN1 (0.84) | PTPN1MEN1KMT2APOLBHDAC2 | |
| SCHEMBL15651643 | 0.86 | KMT2A (0.79) | MEN1KMT2APOLBKDM4ENPC1 | |
| SCHEMBL5004851 | 0.86 | NPC1 (0.68) | PTPN1MEN1KMT2APOLBKDM4E | |
| SCHEMBL26953087 | 0.85 | PTPN1 (0.88) | PTPN1MEN1KMT2APOLBHDAC2 | |
| Phenylguanidine SCHEMBL300643 | 0.85 | TP53 (0.56) | MEN1KMT2ANPC1RAB9APLAU | |
| Phenylguanidine SCHEMBL1950328 | 0.85 | TP53 (0.56) | MEN1KMT2ANPC1RAB9APLAU | |
| SCHEMBL1315526 | 0.84 | PTPN1 (0.87) | PTPN1MEN1KMT2APOLBHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061448-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |