Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylguanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
| ▸ | PLAT | P00750 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylguanidine SCHEMBL1950328 | 1.00 | TP53 (0.56) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL8887604 | 0.98 | TP53 (0.54) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL256023 | 0.93 | ALDH1A1 (0.58) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL11154590 | 0.91 | HSD17B10 (0.59) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL28414520 | 0.91 | HSD17B10 (0.52) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL11092906 | 0.91 | ALDH1A1 (0.56) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL29249611 | 0.91 | ALDH1A1 (0.56) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL4027020 | 0.91 | ALDH1A1 (0.56) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL28765733 | 0.87 | HSD17B10 (0.48) | TP53TSHREPHX1EPHX2CDK9 | |
| Phenylguanidine SCHEMBL10882671 | 0.86 | MAPT (0.52) | TP53TSHREPHX1EPHX2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 259 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119503795-A | Modified activated carbon, silicon-carbon composite material, preparation method thereof, pole piece, application and electrochemical device | 上海杉杉新材料有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-107879953-B | Method and device for recycling phenylguanidine carbonate in wastewater | 南通江山农药化工股份有限公司 | 2023-07-28 | — | — | CN | claimed |
| CN-112813061-A | Pretreatment reagent for nucleic acid extraction of cat body fluid sample and nucleic acid extraction method | 上海基灵生物科技有限公司 | 2021-05-18 | — | — | CN | claimed |
| CN-212293379-U | Phenyl guanidine carbonate crystal particle form lifting device | 南通江山农药化工股份有限公司 | 2021-01-05 | — | — | CN | claimed |
| CN-111747870-A | Process and equipment for improving crystal particle form of phenylguanidine carbonate | 南通江山农药化工股份有限公司 | 2020-10-09 | — | — | CN | claimed |
| CN-111518302-A | Production formula and process of corrosion-aging-resistant insulating tape | 浙江万叶绝缘材料有限公司 | 2020-08-11 | — | — | CN | claimed |
| CN-111362282-A | Production method and system for recycling sodium chloride from phenylguanidine carbonate synthetic wastewater | 利民化学有限责任公司 | 2020-07-03 | — | — | CN | claimed |
| CN-110690516-A | Waste lead-acid storage battery recovery treatment process | 骆驼集团(安徽)再生资源有限公司 | 2020-01-14 | — | — | CN | claimed |
| CN-109161208-A | A kind of high fire-retardance corrosion proof cable material and preparation method thereof | 曹佳男 | 2019-01-08 | — | — | CN | claimed |
| CN-207659355-U | Phenyl guanidine carbonate recovery device in waste water | 南通江山农药化工股份有限公司 | 2018-07-27 | — | — | CN | claimed |
| US-7279577-B2 | Method for producing 2-anilino-4,6-dimethylpyrimidine | DEGUSSA AG (DE) | 2007-10-09 | — | — | US | claimed |
| US-20060127337-A1 | Process for relaxing keratin fibres | L'OREAL (FR) | 2006-06-15 | — | — | US | claimed |
| US-20050154203-A1 | Method for producing 2-anilino-4,6-dimethylpyrimidine | ALZCHEM TROSTBERG GMBH (DE) | 2005-07-14 | — | — | US | claimed |
| EP-1476436-A1 | METHOD FOR PRODUCING 2-ANILINO-4,6-DIMETHYLPYRIMIDINE | Degussa AG (DE) | 2004-11-17 | — | — | EP | claimed |
| WO-2003070708-A1 | METHOD FOR PRODUCING 2-ANILINO-4,6-DIMETHYLPYRIMIDINE | DEGUSSA AG (DE) | 2003-08-28 | — | — | WO | claimed |
| EP-0717038-B1 | Process for the preparation of 2-anilino-pyramidine derivatives | HOECHST SCHERING AGREVO GMBH (DE) | 1998-11-18 | — | — | EP | claimed |
| EP-0717038-A1 | Process for the preparation of 2-anilino-pyramidine derivatives | Hoechst Schering AgrEvo GmbH (DE) | 1996-06-19 | — | — | EP | claimed |
| EP-0560726-B1 | Process for the production of guanidine derivatives | CIBA GEIGY AG (CH) | 1996-05-29 | — | — | EP | claimed |
| US-5276186-A | Process for the production of guanidine derivatives | CIBA-GEIGY CORPORATION (US) | 1994-01-04 | — | — | US | claimed |
| EP-0560726-A2 | Process for the production of guanidine derivatives | CIBA-GEIGY AG (CH) | 1993-09-15 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060127337-A1 | Process for relaxing keratin fibres | KRT18, TPM4, MYLK | TP53 3884/4885TSHR 3657/4885EPHX1 4336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.