Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.40 |
| ▸ | CDK2 | P24941 | 5/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4062061 | 0.99 | HDAC4 (0.45) | HDAC4HDAC1MAPTALDH1A1GAA | |
| SCHEMBL4065919 | 0.80 | MAPT (0.51) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL4065913 | 0.80 | MAPT (0.51) | MAPTALDH1A1MEN1KMT2APOLB | |
| Hydrochloric Acid SCHEMBL27601566 | 0.78 | CCNE1 (0.39) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4060329 | 0.78 | CCNE1 (0.46) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL4234383 | 0.76 | PARP1 (0.47) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4057858 | 0.74 | TLR9 (0.42) | CCNE1CDK2CDK5CDK5R1GSK3A | |
| Hydrochloric Acid SCHEMBL4065193 | 0.74 | FLT3 (0.39) | MEN1KMT2ACCNE1CDK2CDK5 | |
| Hydrochloric Acid SCHEMBL3195081 | 0.74 | MAPT (0.49) | MAPTALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL4061512 | 0.74 | LMNA (0.52) | ALDH1A1SMN1; SMN2L3MBTL1CDK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-B9 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | claimed |
| EP-1492785-B1 | 2-HYDROXY-3-HETEROARYLINDOLE DERIVATIVES AS GSK3 INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-03 | — | — | EP | claimed |